×

Message

EU e-Privacy Directive

This website uses cookies to manage authentication, navigation, and other functions. By using our website, you agree that we can place these types of cookies on your device.

View e-Privacy Directive Documents

View GDPR Documents

You have declined cookies. This decision can be reversed.

Recombinant proteins are often existing as different protein species.

  • N-terminal variants
  • Lysine clipping (C-terminal variants)
  • Internal truncation products
  • N-terminal glutamine cyclization (-> Pyro-Glu)

Proteome Factory offers different services to characterize terminal variants such as peptide mapping after directed proteolysis, N- & C-terminal sequencing and intact mass determination.

 

Further reading:

Dick, L. W., Qiu, D., Mahon, D., Adamo, M. and Cheng, K.-C. (2008), C-terminal lysine variants in fully human monoclonal antibodies: Investigation of test methods and possible causes. Biotechnol. Bioeng., 100: 1132–1143. doi: 10.1002/bit.21855