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The comprehensive analysis of proteins extends over the elucidation of their primary sequence. Especially for recombinant proteins and therapeutic proteins auch as monoclonal antibodies we provide further characterisation including

  • disulfide bridge analysis (elucidation or confirmation of bridges, analysis of mismatches)
  • profiling of glycoforms
  • deamidation analysis
  • lysine-clipping on the C-terminus
  • N-terminal formation of pyroglutamate
  • C-terminal or N-terminal processing variants
  • and other post-translational modifications as required

These analyses are carried out by different proteolytic digests, additional chemical or enzymatical processing, and high resolution mass spectrometry, followed by bioinformatic interpretation of data. Please inquire how we can advance your project.