×

Nachricht

EU e-Privacy Directive

This website uses cookies to manage authentication, navigation, and other functions. By using our website, you agree that we can place these types of cookies on your device.

View e-Privacy Directive Documents

View GDPR Documents

You have declined cookies. This decision can be reversed.

The sensitive and highly specific quantification of biomarkers or other target proteins is done with isotopic dilution and LCMS analyses. This is especially important for 

  • determination of absolute protein amounts
  • when available antibodies exhibit unspecific binding

Feasibility

A proteolytic digest of the sample material in question will be analysed to find suitable proteotypic peptides. Isotopically labelled synthetic mimics of these peptides are obtained for use as internal standards. 

Method development