The comprehensive analysis of proteins extends over the elucidation of their primary sequence. Especially for recombinant proteins and therapeutic proteins auch as monoclonal antibodies we provide further characterisation including

  • disulfide bridge analysis (elucidation or confirmation of bridges, analysis of mismatches)
  • profiling of glycoforms
  • deamidation analysis
  • lysine-clipping on the C-terminus
  • N-terminal formation of pyroglutamate
  • N-terminal processing variants
  • and other post-translational modifications as required

These analyses are carried out by different proteolytic digests, additional chemical or enzymatical processing, and high resolution mass spectrometry.